Rezidivierende Herpes-Iabialis-Infektionen: Zellvermittelte Immunität und Immunomodulation

Journal/Book: Onkologie. 1989; 12: 3-10.

Abstract: The therapy with thymus extracts. oral and parenteral, reduced the frequency and the intensity of recurrences of herpes labialis infections. The duration of the effect was at least 6 month after interruption of the therapy. Indomethacin was effective and developed -and intensive effect only during the therapy.The skin test with recall-antigens and the neopterin-elimination were altered at the first day of the menstruation during the recurrence. The normalisation succeded during therapy.In patients with recurrences in the perimenstrual time we observed a reduced T-helper/T suppressor index during the first day of menstruation.Normal data were registered out of the recurrence time and/or under therapy. Inhibitors of the lymphokin: leucocyte/migration inhibitory factor (LIF) with a molecular weight of 6-12KD were obtained with the specific stimulation of mononuclear cells of patients with recurrent infections with herpes labialis using the herpes-virus-1 antigen. The inhibition of fibrinolysis/proteolysis with aprotinin. tranexamic acid, phenyl-methyl-sulphonyl-fluoride and di-isopropil-fluorophosphate could prevent tire appearance of inhibitors. Inhibitors could be produced by splitting the LIF-molecule with urokinase and plasminogen but not with trypsin.The production, but not the activity. of present LIF-inhibitors arc blocked in vivo and in vitro by indomethacin and thymus peptides.

Keyword(s): LIF

Zurück | Weiter