and J. C. FASCIO

Journal/Book: Separatum EXPERIENTIA 21 141 (1965) Birkhäuser Verlag Basel (Schweiz). 1965;

Abstract: Department of Physiology Facultad de Ciencias Médicas Universidad Nacional de Cuyo Mendoza (Argentine) August 10 1964. Certain biologically active peptides released from plasma proteins under particular conditions have been collectively designated the plasma kinins. They stimulate smooth muscle produce vasomotor changes and increase capillary permeability. Kallidin and bradykinin are vasodilator kinins released from the same plasma substrate1. Bradykinin is a nonapeptide and kallidin a decapeptide having an additional lysyl residue at the N terminal end of the molecule. Both kinins have a strong vasodilator and hypotensive action. Because of their outstanding biological effects and their occurrence in the body plasma kinins are believed to participate in various physiological mechanisms such as vasodilatation. HILTON and LEWIS2-5 have presented evidence that kinin-forming enzymes are released from the submaxillary gland and from the tongue of the cat when vasodilatation was induced by stimulation of the chorda tympani nerve. Similar results were obtained by HILTON and JONES6 on the perfused cat pancreas when the vasodilatation was produced by acetylcholine or by pancreazymin. According to Fox and HILTON7 kinins are released from the human forearm when sweating and thermal vasodilatation is induced and ROCHA E SILVA and ANTONIO8 by heating the rat's leg to 44-45°C found a rise of the kinin content of the fluid perfusing the subcutaneous tissue. On the other hand muscle vasodilatation that follows stimulation of the motor nerve does not appear to be mediated by kinin release5. All the above-mentioned experiments were carried out using electrolyte solutions as the perfusing fluid. We decided to investigate the kinin content of the venous blood of the human forearm during vasodilatation produced by heating or by exercise. ... ___MH

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