THE USE OF Na22 TO STUDY THE SODIUM-RETAINING PROPERTIES OF STEROID THERAPY IN RHEUMATOID ARTHRITIS

Journal/Book: JOURNAL OF CHRONIC DISEASES Vol. 12 No. 2 Pages 243-251 August 1960. 1960;

Abstract: BARBARA M. ANSELL M.B. M.R.C.P. AND RALPH E. BERNSTEIN M.Sc. M.B. D.C.P.* LONDON ENGLAND From the Departments of Medicine and Chemical Pathology Postgraduate Medical School of London Received for publication Jan. 2 1960 Work performed during tenure of at C. J. Adams Fellowship. *Present address for reprint requests Pathologist and Head Electrolyte and Metabolic Research Unit South African Institute for Medical Research Johannesburg South Africa. SUMMARY 1. Following the oral administration of Na22 the biologic decay of sodium and the total exchangeable sodium were followed with the use of a total body counter and a single daily urine sample. This proved to be a satisfactory method for studying the trend in body sodium. 2. The administration of cortisone 75 to 200 mg. per day to patients with long-standing rheumatoid arthritis was associated with sodium retention which did not occur with prednisolone in the dose range of 15 to 50 mg. per day. Fluid accumulation evidenced by a rise in body weight accompanied the sodium retention. 3. Prednisolone had a natriuretic effect in certain situations. ___MH

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