URINARY CORTICOSTEROID EXCRETION PATTERNS IN PATIENTS WITH ADRENOCORTICAL DYSFUNCTION

Journal/Book: Reprinied from THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM Vol. XVIII No. 4 1958 pp. 391-408. 1958;

Abstract: McGill University Clinic Royal Victoria Hospital and the Department oJ Investigative Medicine McGill University Montreal Canada ABSTRA

Keyword(s): A technique is described for obtaining patterns of the urinary excretion of steroids containing 4-3-keto- and -ketolic groupings. The patterns in normal subjects showed the presence of pregnane-3 11 17 21-tetrol-20-one (THF) pregnane-3 17 21-triol-11 20-dione (THE) cortisol (compound F) cortisone (compound E) and 5 unidentified compounds X1 X6 X9 X10 and X11. In addition corticosterone (compound B) was excreted in 1 patient and pregnane-3-11 21-triol-20-one (THB) in 2 normal subjects. CompoundsTHE an THF were the chief metabolites. In 3 patients with Cushing's syndrome similar compounds were present an the paper chromatograms. However they were excreted in much larger amounts. . . . .

Zurück | Weiter