THE RELATIONSHIP BETWEEN AIRWAY RESISTANCE AIRWAY CONDUCTANCE AND LUNG VOLUME IN SUBJECTS OF DIFFERENT AGE AND BODY SIZE 1 2

Journal/Book: Reprinted from THE JOURNAL OF CLINICAL INVESTIGATION VOI. 37 No. 9 pp. 1279-1285 September 1958. 1958;

Abstract: (From the Department of Physiology and Pharmacology The University of Pennsylvania Graduate School of Medicine Philadelphia Pa.) (Submitted for publication April 1 1958; accepted April 25 1958) 1 This investigation was supported in part under a contract between the Army Chemical Center and the Graduate School of Medicine University of Pennsylvania. 2 Presented in preliminary form at the Fall Meetings of the American Physiological Society 1956. 3 Present address: Cardio-Pulmonary Laboratory (Columbia University Division) Bellevue Hospital New York N. Y. 4 Established Investigator of the American Heart Association. The resistance of the airways to the airflow through them depends an the radius length and number of the airways. It has long been apparent (1 2) that the bronchi are distended as well as lengthened in the inspiratory position of the lung. These two changes in the dimensions of these airways would have opposite effects an their resistance to airflow lengthening increasing resistance and widening reducing it. More recent measurements of airway resistance have shown that it is reduced in the inspiratory position of the lung (3 4 5) and is more in individuals with small lungs (6). The body plethysmograph affords a good technique for comparing changes in airway resistance with changes in lung volume in an individual since each measurement of airway resistance includes as an essential stage in its derivation a measurement of intrathoracic gas volume. It therefore seemed desirable to explore further the relationship between airway resistance and lung volume at different degrees of inflation of the lung in normal subjects. schö

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