Liposomes from Soya Phospholipids as Percutaneous Drug Carriers

Journal/Book: Arzneim.-Forsch./Drug Res. 40 (II) 12 1365-1368 (1990). 1990;

Abstract: Institut für Medizinische Balneologie und Klimatologie der Ludwig-Maximillians-Universitäta Munich and Nattermann Phospholipid GmbHb Cologne (Fed. Rep. of Germany) Summary The percutaneous absorption of liposomes (prepared from NAT 106) was investigated with radioactively Iabelled substances in comparison with percutaneous absorption without liposomes (controls) in vivo on the skin of young pigs. Radioactivity was monitored as a function of time in skin tissue plasma or blood and in urine. Elevated tissue levels increased absorption and renal elimination of the various Iiposomal preparations in comparison to the controls were measured. hl

Keyword(s): Drug carriers percutaneous Heparin Liposomes absorption penetration Phosphatidylcholine Sodium pertechnate

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