Analysis of catechol-O-methyltransferase and 5-hydroxytryptamine transporter polymorphisms in patients at risk for suicide

Author(s): Lachman, H. M., Kashdan, T., Saito, T., BajmakovicKacila, S.

Journal/Book: Psychiat Res. 2000; 93: Customer Relations Manager Bay 15, Shannon Industrial Estate CO, Clare, Ireland. Elsevier Sci Ireland Ltd. 73-78.

Abstract: Genotype frequencies of functional polymorphisms in the genes encoding the serotonin transporter (5-HTT) and the enzyme catechol-O-methyltransferase (COMT) were not different in 51 suicidal inpatients compared to 51 control subjects. Within the patient group, increased hopelessness and suicide ideation were associated with homozygosity of the 5-HTT high promotor activity allele.

Note: Article Russ MJ, Hillside Hosp, N Shore Long Isl Jewish Hlth Syst, 75-59 263rd St, Glen Oaks,NY 11004 USA

Keyword(s): hopelessness; serotonin; major depression; BIPOLAR AFFECTIVE-DISORDER; FUNCTIONAL POLYMORPHISM; GENE POLYMORPHISMS; MAJOR DEPRESSION; ASSOCIATION; HOPELESSNESS; SCHIZOPHRENIA; PHARMACOGENETICS; IDEATION; BEHAVIOR

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