Current issues in depression in Parkinson's disease

Author(s): Gold, M., Chari, G., Hauser, R. A.

Journal/Book: Amer J Geriatr Psychiatr. 1999; 7: 1400 K St N W, Ste 1101, Washington, DC 20005, USA. Amer Psychiatric Press, Inc. 110-118.

Abstract: Depression affects 40%-50% of Parkinson's disease (CPD) patients. The authors, by use of a Mednet and manual search of pertinent literature, summarize current issuses in the treatment of anti depression in PD. Open-label studies suggest that antidepressants ts may be effective a treating depression Zn PD. Although case reports indicate that selective serotonin I reuptake inhibitors (SSRIs) can potentially zcworsen motor symptoms, of PD, this effect has not been confirmed in, tthe small number Of open-label Studies that have been performed to date. The occurrene of th serotnin syndrome,resulting from t a combination of selegiline and nit SSRI appears to be rare. Double-blind prospective studies nit needed to evaluate the saftey and efficancy of antidepressants, and their effect on motor function.

Note: Article Hauser RA, Univ S Florida, Coll Med, Pakinsons Dis & Movement Disorders Ctr, 4 Columbia Dr, Suite 410, Tampa,FL 33606 USA

Keyword(s): LEWY-BODY-DISEASE; EXTRAPYRAMIDAL SYMPTOMS; PSYCHIATRIC-SYMPTOMS; ALZHEIMERS-DISEASE; SEROTONIN SYNDROME; L-DOPA; FLUOXETINE; DEMENTIA; SELEGILINE; ANTIDEPRESSANT

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