Heilpflanzen-Welt - Die Welt der Heilpflanzen!
Heilpflanzen-Welt - Natürlich natürlich!
November 2021

Mismatch negativity and N2b attenuation as an indicator for dysfunction of the preattentive and controlled processing for deviance detection in schizophrenia: a topographic event-related potential study

Author(s): Okazawa, K., Nakagome, K., Hiramatsu, K. I., Hata, A., Fukuda, M., Honda, M., Miyauchi, M., Matsushita, M.

Journal/Book: Schizophr Res. 1999; 35: PO Box 211, 1000 AE Amsterdam, Netherlands. Elsevier Science Bv. 141-156.

Abstract: The present study compares the amplitudes and topographic patterns of mismatch negativity (MMN) and N2b in schizophrenic patients and normal controls. Twenty-one schizophrenic outpatients and 19 normal volunteers participated in the study. Event-related potentials (ERPs) were recorded in a selective attention task. During the task, subjects were required to focus on one ear, counting deviant stimuli, those deviating in duration from a sequence of standard stimuli. MMN was significantly attenuated in the schizophrenics as compared with the normals in the frontocentral regions. In addition to MMN, the N2b amplitude was also reduced, which showed a significant correlation with the MMN amplitude in the schizophrenics. The late negativity elicited by the deviant stimuli in the unattended condition showed different topographical features between the groups. Whereas the normals showed a lateralized distribution with an ear-related asymmetry, similar to that of the N2b, the schizophrenics showed a frontal dominance, coinciding with the sustained negativity reported by Naatanen et al. (1982), which reflects the automatic preparation for detecting possible subsequent stimulus changes. The amplitude of the sustained negativity was significantly correlated with the performance level in the schizophrenics. The results indicated that although both preattentive and controlled processings are impaired, schizophrenic patients, presumably due to the deficient controlled processing, owe much to automatic processing in the deviant stimulus detection process.

Note: Article Kasai K, Univ Tokyo, Fac Med, Dept Neuropsychiat, Bunkyo Ku, 7-3-1 Hongo, Tokyo 113, JAPAN

Keyword(s): mismatch negativity; N2b; event-related potentials; selective attention task; topography; schizophrenia; SELECTIVE-ATTENTION; STIMULUS DEVIANCE; AUDITORY-CORTEX; DEFICIT; DISCRIMINATION; ABNORMALITIES; IMPAIRMENT; RESPONSES; MEMORY; MODEL


Search only the database: 

 

Zurück | Weiter

© Top Fit Gesund, 1992-2021. Alle Rechte vorbehalten – ImpressumDatenschutzerklärung