Refractory symptomatic schizophrenia resulting from frontal lobe lesion: response to clozapine

Author(s): Dursun, S. M., Reveley, M. A.

Journal/Book: J Psychiatr Neurosci. 1999; 24: 1867 Alta Vista Dr, Ottawa, Ontario K1G 3Y6, Canada. Canadian Medical Association. 456-461.

Abstract: A 34-year-old man with a 10-year history of persistent auditory hallucinations and passivity delusions had failed to respond to a variety of conventional antipsychotic medications. He had a history of head trauma 8 years before the onset of psychiatric symptoms. Recent investigations revealed a post-traumatic infarct, situated in the left frontal lobe, on a magnetic resonance imaging scan. Treatment with clozapine for more than 2 years resulted in a marked improvement in his psychotic symptoms. The localization of the brain lesion may be related to the etiology of his symptoms: and to the clinical response to clozapine.

Note: Article Dursun SM, Dalhousie Univ, Psychopharmacol Res Unit, Dept Psychiat, AJLB, 5909 Jubilee Rd, Room 4031, Halifax, NS B3H 2E2, CANADA

Keyword(s): brain injuries; clozapine; epilepsy, post-traumatic; frontal lobe; head; head injuries; schizophrenia; trauma

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