Antimicrobial, antitumor and antileishmania screening of Medicinal Plants from Guinea-Bissau

Author(s): Martins, E., Kayser, O., Bindseil, K. -U., Siems, K., Seemann, A., Frevert, J.

Abstract: Following an ethnobotanical search carried out in Guinea-Bissau, eighteen extracts derived from sixteen medicinal species were screened for antimicrobial, antitumor and antileishmania activity. Significant antitumor activity was found for Holarrhena floribunda against KB (squamous carcinoma), SK-Mel 28 (melanoma), A 549 (lung carcinoma) and MDA-MB 231 (mamma carcinoma) cell lines, with corresponding IC50 values of 7.9, 9.0, 3.4 and 9.9 mg/ml. Khaya senegalensis and Anthostema senegalense exhibited a significant activity against Leishmania donovani with C50 values of 9.8 and 9.1 mg/ml, respectively. Most of the extracts showed week or moderate antibacterial and antifungal activity, with MIC values in the range 0.25-1.0 mg/ml. Active extracts were submitted to bioassay-guided fractionation, and the 1C50 and MIC of the active fractions were determined.

Keyword(s): Medicinal plants

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