The Treatment of Rheumatoid Arthritis (RA) and it's Complications in Aged Patients

Journal/Book: Z Rheumatol 1998; 57 Suppl. 1: 76 (P 127). 1998;

Abstract: Institute of Rheumatology RAMS Moskow 141 patients (pts) with RA (m/f - 30/111) with the mean age 60.1 years (yrs) were followed up (mean follow up period - 7.5 yrs). The acute onset of disease and generalized joint involvement had 90 % of pts early appearence of Rheumatoid factor had 80 % early destructive changes in joints 80 % rheumatoid nodules - 18 % pts. All of them had different degree of osteoporosis that was proved by densytometry in 19 pts it was very severe mth spontaneous bone fracture (14 pts) and spondylopathy (5 pts) "fish-like" and clinoid compression of vertebral bodies. Most of pts had hyperrtonia. atherosclerosis cardiosclerosis. diabetis mellitus and other. All of pts recieved aminochinolin drugs and NSAID. Corticisteroids (Cs) recieved 54 % of pts from 2months to 15 yrs (2 pts were treated with puls-therapy with solumedrole). Intraarticular injection of Cs obtained all pts (1 - 6 time in a year). Cytotoxics (C) recieved 38 % of pts sulfasalazine 10 %. tauredone - 6 % pts 21 % of pts ivere treated only with aminochinolin drugs and NSAID. Analisis showed that the mean dose of Cs in the pts with the bone fractures was 12 4 gr (from 7.3 to 43.0) and in the pts with spondylopathy 24.7 (from 16.4 to 43.8) gr. Pts with systemic manifestations and pathology of vessels (Raynauds syndrome) vasculitis recieved pento-fylline solcoseryl. curantyl. All the pts were treated with drugs. that improved metabolic disorders in bones such as sodium fluorid (coreberon ossin) calcitonin derivates of vitamin D (vitamin D3). Miacalcic recieved 1/3 of pts mostly with severe osteoporosis. Thus the treatment had favorable effect: in 90 % decreased of disability 6 % of pts had remission during 1 - 7 and more yrs. ... le

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