Immunzelluläre Veränderungen als diagnostische Wegweiser bei gastrointestinalen Syndromen

Author(s): Bayer, W., Schmidt, K.

Abstract: The majority of severe intestinal diseases is accompanied by immune cellular deviations or is even caused by a too weakly reacting or impaired immunity. Because it is often a predominant issue in a stepwise diagnostic procedure to first eliminate gastrointestinal symptoms from being only a reflectance of psycho-vegetative disorders, but conversely the exclusion of an organ disease can hardly be made only via the usage of the traditional and often poorly indicating inflammatory lab parameters, an increased interest comes up to the method of lymphocyte phenotyping, which has a much better sensitivity and more directly explores the disease-inherent alteration of the defense system. Both immunodeficiencies and reactivity phenomena were easily detected, and if the latter are marked, they can even argue for underlying chronic inflammatory bowel diseases and autoimmunopathies. A representative case is reported for a female patient with an intestinal fungal infection exhibiting a deficiency in the cellular limb of immunity. More broadly reported are the preferential immune cell alterations exhibited from patients who were suffering from Crohn's disease and ulcerative colitis. The two disease entities, though being pathogenetically equally dominated by the ongoing inflammatory and autoaggressive process, differ each another in major items of the cellular immune profile.

Keyword(s): Gastrointestinalerkrankungen

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