Case study: Adverse effects of smoking marijuana while receiving tricyclic antidepressants

Author(s): Biederman, J., Spencer, T. J.

Journal/Book: J Amer Acad Child Adolesc Psy. 1997; 36: 351 West Camden St, Baltimore, MD 21201-2436. Williams & Wilkins. 45-48.

Abstract: increasingly, children and adolescents are being treated for underlying psychopathology commonly associated with the psychoactive substance use disorders. Despite this apparent increase in using medication, little is known about the interaction of drugs of abuse with the psychotropic medications. The authors describe four cases of male adolescents aged 15 to 18 years being treated with a tricyclic antidepressant for attention-deficit hyperactivity disorder who manifested transient cognitive changes, delirium, and tachycardia after smoking marijuana.

Note: Article Wilens TE, Massachusetts Gen Hosp, Pediat Psychopharmacol Unit, ACC 725, Boston,MA 02114 USA

Keyword(s): tricyclic antidepressant; marijuana; pediatric; adverse effects; ATTENTION-DEFICIT HYPERACTIVITY; ADOLESCENT SUBSTANCE-ABUSERS; PSYCHIATRIC COMORBIDITY; USE DISORDERS; DEPRESSION; ANXIETY; ADHD; BOYS

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