Garlic in hyperlipidemia. Influence of a garlic preparation on the lipid serum levels of patients with primary hyperlipidaemia

Author(s): Hein, T.

Abstract: The lipid lowering effect of an enteric coated garlic/cyclodextrine preparation (Tegra®) was investigated. 97 patients with known primär hyperlipidaemia (serum levels of total cholesterol exceeding 260 mg/100 ml) took part in this trial. Patients received 10 mg/day of essential garlic oil obtained by steam distillation of garlic. The trial was carried out of 3 months and for 6 months in those cases in which the aim of the treatment (reduction of serum levels of total cholesterol to values less than 260 mg/100 ml) had not been reached after 3 months. Most of the patients did not alter their diet, though they were advised to do so. In 28 of 97 patients the treatment was successful after 3 months. The total cholesterol (TC) decreased by 7.8% from 287 to 264 mg/100 n-A in the mean, the triglycerides (TG) by 2.2% from 205 to 180 mg/100 ml, the low-density lipoprotein cholesterol (LDL-C) by 10.2% from 207 to 186 mg/100 n-d. The high-density lipoprotein cholesterol (HDL-C) increased by 10% from 38.8 to 42.6 mg/100 n-d. Continuing the trial for a further three months in 69 patients resulted in an overall reduction of TC by 14.1% to 246 mg/100 ml, of TG by 20.2% to 164 mg/100 ml, and of LDL-C by 18.8% to 168 mg/100 ml. HDL-C values in the same time increased by 176% to 45.6 mg/100 ml. All changes were statistically significant (p < 0.001). The aim of the treatment was reached by 90% of the patients (87 of 97). All patients had a reduction of TC, TG and LDL-C and an increase in HDL-C. No severe side effects were observed. The results of the study demonstrate the efficacy of essential garlic oil/ß-cyclodextrine complexes in the treatment of hyperlipidaemia.

Keyword(s): Garlic

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