Probiotische Behandlung der chronischen Obstipation

Abstract: Changes of intestinal microflora in constipated patients, like reduction of total microbial counts, decrease of Bifidobacteria and of normal nonpathogenic E. coli, increase of Bacteroides, show that relationship exist between a disturbed intestinal flora and chronic idiopathic constipation. After in several case-reports a positive effect of a probiotic treatment of chronic constipation by the E. coli strain Nissle 1917 (Mutaflor®) has been described, therapeutic efficacy and tolerability where proved in two controlled clinical studies. In the first study an equivalence of Mutaflor® treatment with the standard prescription lactulose has been shown. In the second study being conducted as a placebo-controlled double-blind study, a significant superiority of probiotic treatment with the E. coli preparation compared to placebo could be demonstrated.

Keyword(s): Chronische Obstipation

Zurück | Weiter