Zur Permeation von organischen Stoffen durch Humanhaut

Author(s): Beer, A. -M.

Abstract: The permeation of contents of peat through human skin has been proofed on the change of the tonic and the phasic activity from smooth muscles.For proofing the permeation from organical materials through human skin, special preparations from tissue were made and the tissue was brought between two chambers of a permeation model.Organical substances of peat were investigated in this model with different tissues in puffer solution dependent on the time. Then the changes of contractility of the smooth muscles under the test-solution which contains the permeation material and under the blind-solution, which contains the puffer, were investigated on guinea-pig stomach.The dosis dependent effect of the test-solution and the blind-solution on the contractility of smooth muscles has been shown.Moreover an inhibition of contractility of the smooth muscles has been found after incubating in test-solution. Not only the permeation of peat contents through human skin has been proofed, but also the permeation of biologically effective peat contents.

Keyword(s): Permeation

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