Staining of cerebral amyloid plaque glycoproteins in patients with Alzheimer´s disease with the microglia-specific lectin from mistletoe

Journal/Book: Acta Neuropathol. 87 (14), 422-424. 1994;

Abstract: Glycoconjugates in the amyloid plaques in the cerebral cortex ofpatients with Alzheimer's disease were stained with a lectin frommistletoe (ML-I). This lectin selectively stains microglial cells whichcan be found in the centre of many plaques. Since the terminalcarbohydrate moieties of some but not all of the plaques, which mainlyconsist of beta A4 protein, are identical to those of the microglialcells it is concluded that glycoproteins within these plaques have beensynthesised by the microglial cell. These microglia depositedglycoproteins may be of importance for the formation of mature amyloidplaques. Author.

Keyword(s): ALZHEIMERS-DISEASE/ ME (metabolism)

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