Modulation of lectin-triggered superoxid release from neutrophils of tumor patients with and without chemotherapy

Journal/Book: Anticancer Research 13 (5c), 1789-1792. 1993;

Abstract: Superoxide production by neutrophils is believed to contribute to theefficiency of the host defence system. This activity is stimulated bythe mannose-specific lectin concanavalin A, theN-acetylglucosamine/neuraminic acid-specific wheat germ agglutinin andthe galactoside-specific lectins from Viscum album and human placenta.To assess whether this aspect of immune function is affected in cancerpatients without or with treatment, neutrophil preparations from 69patients were examined. Reductions in O2.(-)-production were observedfor bronchial carcinoma patients after incubation with concanavalin Aand the human lectin, while samples from breast cancer patients withoutor with treatment exhibited no significantly altered activity in thepresence of each of the four agglutinins. Chemotherapy of lung andcolorectal carcinoma patients reduced the neutrophilic response toconcanavalin A and Viscum album agglutinin. As similarly shown for 9specimens from other carcinoma types and from hemopoietic malignancies,there is no general impairment of responsiveness. In addition to theproperty of the lectin, the large extent of interindividual variationshould be taken into account when it is attempted to enhance this factorof the host defence system against infections and malignant cells.Author.

Keyword(s): ADULT

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