Dynamic training and circulating levels of corticotropin-releasing factor, beta-lipotropin and beta-endorphin in rheumatoid arthritis

Author(s): Ekman, R., Andersson, S., Melander, A., Svensson, B.

Journal/Book: Pain. 1990; 40: 35-42.

Abstract: The study aimed al evaluating the effects of a dynamic training program on circulating levels of corticotropin-releasing factor (CRF). beta-lipotropin (?-LPH), and beta-endorphin (?-EP) in 8 patients (5 females and 3 males, aged 39-65 years) with classical/definite rheumatoid arthritis (RA). Blood samples were collected immediately before, in the middle of. and after a 6-week high-intensity training period as well as after a subsequent 1-year period of low-intensity training. In addition. baseline data were obtained 3 weeks before the start of the training program. Use of multivariate analyses of variance, and of analyses of variance of contrast variables, indicated a short-term effect of the high-intensity training program for ?-EP with increased levels (P < 0.05) between the 3rd and the 6th weeks, no significant differences being obtained for CRF or ?-LPH here. Corresponding analyses with regard to the combined high and low-intensity training program revealed CRF (P < 0.01). and ?-LPH (P < 0.01) levels to increase over time, no long-term effect being found for ?-EP. Despite the intensity of the dynamic training program, no change was found in pain experience as measured on a visual analogue scale.

Keyword(s): Rheumatoid arthritis

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