Silymarin (Legalon) kezelés hatása idült alkoholos májbetegek antioxidáns vádörendszerére és a lipid peroxidációra (kettös vak protokoll)

Author(s): Deák, G., Láng, I., Nékám, K., Niederland, V., Fehér, J.

Journal/Book: Orvosi Hetilap. 1990; 131, 16:

Abstract: Antioxidant and antiperoxidative effects of the free radical scavenger agent silymarin (Legalona) were investigated in patients with chronic alcoholic liver disease in a double-blind clinical trial. Six-month treatment (at a daily dose of 420 mg) with silymarin significantly enhanced the originally low superoxide dismutase activity of erythrocytes and lymphocytes and also restored the diminished superoxide dismutase expression an lymphocytes as measured by flow-cytofluorimetry. In addition, silymarin therapy markedly increased the serum level of free -SH groups and the activity of glutathione peroxidase. In contrast, a considerable fall in serum malondialdehyde concentration was detected in patients having received silymarin. However, in case of placebo-treated patients the above mentioned parameters of the antioxidant defence system and lipid peroxidation failed to change significantly. These data indirectly suggest that antioxidant, antiperoxidative effects might be important factors in the mechanism of the hepatoprotective action of silymarin.

Keyword(s): Chronic alcoholic liver disease

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