Dietary Sodium Restriction: Adverse Effect on Plasma Lipids
Author(s):, , ,
Journal/Book: Klinische Wochenschrift. 1990; 68: 664-668.
Abstract: In order to examine the effect of dietary sodium intake an plasma lipids, I5 healthy male volunteers were given a low-salt diet (20 mmol/ day) for 3 weeks, adding either placebo, sodium chloride (200 mmol/day), or a non-chloridc sodium salt (sodium citrate, 200 mmol Na/day) for one week each, in a single-blind randomized crossover study.Plasma levels of total cholesterol and LDL choIesterol were significantly higher at the end of the placebo period than with either sodium chloride (by 8.7 and 11.9%, respectively) (P<0.005) or sodium citrate (by 11.3%, and 16.8%, respectively) (P<0.005). Thus this effect was dependent an sodium but not an chloride intake. Triglyceride and HDL-cholesterol levels were not afflicted by the dictary regimens. We conclude that short-term dietary sodium restriction may lead to a rise in plasma total and LDL cholesterol, thereby possibly increasing the risk of atherosclerotic vascular disease. Our findings render it possible that diuretic-induced lipid disturbances may also bc caused by sodium depletion.
Keyword(s): Dietary salt restriction