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Antineoplastic properies of Maharishi-4 against DMBA-induces mammary tumors in rats

Author(s): Dwivedi, C., Satter, B., Gudehithlu, K., Abou-Issa, H., Malarkey, W., Tejwani, G.

Journal/Book: Pharmacology Biochemistry & Behavior. 1990; 35: 767-773.

Abstract: Maharishi-4 (M-4), an ayurvedic food supplement, was tested for anticarcinogenic and anticancer properties against 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in rats. The 6% M-4-supplemented diet protected DMBA-induced carcinogenesis by reducing both tumor incidence and multiplicity during initiation and promotion phases. The control animals who developed tumors when supplemented with M-4 diet for four weeks showed tumor regression in 60% of cases. There was no significant difference in the food intake or weight gain in rats who were an M-4-supplemented diet compared to control group. Possible mechanisms of action of M-4 are discussed.

Keyword(s): Antineoplastic

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