Immunomodulatory effects of Iscador: A VISCUM ALBUM preparation
Journal/Book: Oncology 43: suppl. 1, 51-65. 1986;
Abstract: The immunomodulatory effects of Iscador (a mistletoe, Viscum albumextract) were investigated. After a single intravenous infusion ofIscador several immunological parameters in the peripheral blood ofbreast cancer patients were examined. Parallel with neutrophilia, andwith an increase of juvenile neutrophils, a significant enhancement ofphagocytic activity of granulocytes was shown. After short decreasesduring the first 24 h, significant increases in natural killer (NK) andantibody-dependent cell-mediated cytotoxicity (ADCC) activities as wellas augmented levels of large granular lymphocytes were observed. TheseNK/ADCC responses followed a kinetic pattern similar to that aftertreatment with alpha-interferon described by others. Further significantincreases in mitogenic responses to phytohemagglutinin and concanavalinA were observed. Author.
Keyword(s): ADJUVANTS-IMMUNOLOGIC/ PD (pharmacology)