Antidepressive Wirkung eines auf den Wirkstoffkomplex Hypercin standardisierten Hypericum-Extraktes. Biochemische und klinische Untersuchungen

Author(s): Zöller, M.

Journal/Book: Arzneim-Forsch/Drug Res. 1984; 34: 918-920.

Abstract: In 6 women with depressive symptoms aged 55-65 years the effect an the excretion of urinary metabolits of noradrenaline and dopamine was measured after a monotherapy with the active hypericine complex (Psychotonin® M). In all patients there was a significant increase in 3-methoxy-4-hydroxyphenylglucol which is considered an expression of a beginning antidepressive reaction.With the same patients supplemented with further 9 cases the clinical influence an the depression was measured during a period of 4-6 weeks. with the rating-scales SCAG (Clinical assessment geriatric scale) and DSI (Depression Status Inventory) there was shown a quantitative improvement of the items anxiety, dysphoric mood, loss of interest, hypersomnia, anorexia, depression regularly worse in the morning, insomnia, obstipation, psychomotoric retardation and feeling of worthlessness.Side effects did not occur,- EEG, ECG and laboratory Parameters did not change.

Keyword(s): Antidepressants

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