Carcinogenic activity of Symphytum officinale

Author(s): Moritt, Haga, M.

Journal/Book: Journal of the National Cancer Institute. 1978; 61: 865-869.

Abstract: The carcinogenicity of Symphytum officinale L., Russian comfrey, used as a green vegetable or tonic, was studied in inbred ACI rats. Three groups of 19-28 rats each were fed comfrey leaves for 480-600 days; tour additional groups of 15-24 rats were fed comfrey roots for varying lengths of time. A control group was given a normal diet. Hepatocellular adenomas were induced in all experimental groups that received the diets containing comtrey roots and leaves. Hemangioendothelial sarcoma of the liver was infrequently induced.

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