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September 2022

Stabilization of Isolated Rat Liver Plasma Membranes by Treatment in vitro with Silymarin

Author(s): Meldolesi, J.

Journal/Book: Arzneim-Forsch/Drug Res. 1974; 24: 806-808.

Abstract: Isolated rat liver plasma membranes appear considerably stabilized by in vitro treatment with silymarin, as evidenced by their decreased susceptibility to the solubilizing activity of the ionic detergent Na deoxycholate. The effect is evident for drug concentrations between 0.5 and 10 mM and is not reversed by membrane washing. The possible significance of the phenomenon is discussed.

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