THE CORRELATION BETWEEN SERUM AND TISSUE LEVELS OF ENZYMES IN SIX VERTEBRATE SPECIESSTUDIES ON LACTATE DEHYDROGENASE PHOSPHOHEXOSE ISOMERASE ALDOLASE AND MALATE DEHYDROGENASE*

Journal/Book: Comp. Biochem. Physiol. 1969 Vol. 28 pp. 1193 to 1198. Pergamon Press. Printed in Great Britain. 1969;

Abstract: The Liver and Metabolic Research Laboratory Veterans Administration Hospital Washington D.C. and the Department of Medicine The George Washington University School of Medicine Washington D.C. Abstract 1. The content of aldolase (ALD) lactate dehydrogenase (LDH) phosphohexose isomerase (PHI) and malate dehydrogenase (MDH) in the brain heart kidney liver and muscle of six species (guinea-pig rabbit pigeon chicken rat and horse) was measured. In these species the serum levels of the enzymes cover a wide range. 2. For each of the enzymes studied there was a tendency for the animals with the highest and lowest serum values to have the highest and lowest levels in their tissues respectively. 3. For each of the six species studied the sequence for the values of the four enzymes was consistent. ALD LDH PHI and MDH appeared in the same order of increasing activity in the serum and tissues of almost every species. The only deviations from this pattern were found for serum PHI and MD of the guinea pig and tissue PHI of the chicken. 4. In general the higher the level of enzyme in the serum of a species the greater the concentration of the respective enzyme in their tissues.

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