METABOLIC STUDIES ON SKIN

Journal/Book: THE JOURNAL OF INVESTIGATIVE DERMATOLOGY VOI. 50 NO. 2 III. LIPID METABOLISM IN MOUSE SKIN DURING THE HAIR GROWTH CYCLE*. 1967/1968;

Abstract: Accepted for publication July 20 1967. * From the Detroit Institute of Cancer Research Division of the Michigan Cancer Foundation and Wayne State University School of Medicine Department of Biochemistry Detroit Michigan 48201. SUMMARY Metabolic studies an mouse skin were under taken to determine the effect of the hair growth cycle an the metabolism of fatty acids and sterols. Gas-liquid chromatography was employed to analyze and to isolate the lipids from incubations with acetate-1-C14. Substantial increases in the lipid and oxidative metabolism of skin were demonstrated during the first week of hair growth. During this period of anagen there was a decrease in the concentration of certain fatty acids and a concurrent accumulation of cholesterol in the skin. The oxidation of fatty acids was shown to increase; this route appears to be a significant source of energy during the early phases of hair growth. Thinning of the epidermis at 9 days was accompanied by a decrease in the synthesis of cholesterol and a resultant accumulation of a metabolically inactive Pool of 7-sterols. Fatty acids were shown to become more concentrated during the latter phases of hair growth. schö

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