SEASONAL VARIATION IN SERUM CHOLESTEROL CONCENTRATION

Journal/Book: J. chron. Dis. 1965 Vol. 18 pp. 657-664. Pergamon Press Ltd. Printed in Great Britain. 1965;

Abstract: The Cardiovascular Health Center Albany Medical College and The New York State Department of Health Albany New York *Professor of Medicine and Head of the Sub Department of Cardiovascular Medicine and Director of the Cardiovascular Health Center Albany Medical College. Principal Biostatistician New York State Department of Health. Assistant Professor of Medicine and Associate Director of the Cardiovascular Health Center Albany Medical College. SUMMARY AND CONCLUSIONS The STCC of a group of 69 men free of CHD was measured at monthly intervals for one year and at daily intervals during one week in this period. The analytical procedure was rigorously controlled and the technical error of the method remained within satisfactory limits during the study period. The monthly mean STCC was lowest in July and December and highest in November and February. The proportional change in STCC was remarkably constant. Significant day-to-day changes in STCC did not occur. The STCC measured in the same season of the year tends to be fairly constant. Spontaneous variation in STCC must be taken into account in the evaluation of cholesterol-lowering regimens. The cause of seasonal variations in STCC is unexplained. . . .

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