Effect of some drugs on reflex vasodilatation of hand produced by radiant heating of trunk

Journal/Book: J. Appl. Physiol. 19(5) : 995-998. 1964. 1964;

Abstract: Department of Neurology Harvard Medical School Massachusetts General Hospital Boston Massachusetts and Institute of Neurology The National Hospital London England Received for publication 24 February 1964. 1 Postgraduate Training Fellowship in Medicine from the University of Sydney. The effect of some drugs an reflex vasodilatation in the hand was studied. Bretylium tosylate and phenoxybenzamine abolished the reflex vasodilator response in the hand caused by cradle heating of the chest. Alpha methyl dopa nethalide and atropine had no effect an this response. It is suggested that the tonic constriction of hand vessels maintained by sympathetic fibers and alpha adrenergic constrictor receptors is temporarily interrupted by 40 sec cradle heating of the chest and that this produces the observed increase in hand blond flow. The reflex increase in hand blood flow with short cradle heating of the chest appears to utilize a common efferent pathway with the vasodilator response produced in the band by prolonged heating of the legs. On the afferent side however these reflexes use different mechanisms.

Keyword(s): afferent and efferent pathways - alpha methyl dopa - nethalide - atropine receptors on hand vessels - bretylium tosylate - phenoxybenzamine

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