Detection of Halogenated Hydrocarbons in the Expired Air of Human Beings using the Electron Capture Detector

Journal/Book: (Reprinted from Nature Vol. 198 No. 4881 pp. 696-697 May 18 1963). 1963;

Abstract: Medical Research Laboratory and East Analytical Laboratory Dow Chemical Co. Midland Michigan. THE infra-red analysis of expired air from persons exposed to solvent vapours is affording toxicologists and physicians a means for specifically identifying the majority of organic solvents in the immediate post-exposure period1-4. The length of time a specific compound may be detected in this post-exposure period is dependent on the sensitivity of detection the magnitude and duration of the exposure and the rate of excretion and metabolism of the compound. In the case of the halogenated hydrocarbons this sensitivity of detection may be greatly increased by the use of the electron·capture-equipped gas chromatograph. This may extend the length of time during which many of these compounds may be detected in the expired breath to several weeks in the post-exposure period. . . .

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