WATER AND SALT ABSORPTION IN THE HUMAN COLON *

Journal/Book: Journal of Clinical Investigation Vol. 41 No. 9 1962. 1962;

Abstract: From the Robert Dawson Evans Memorial the Massachusetts Memorial Hospitals and the Department of Medicine Boston University School of Medicine Boston Mass. Submitted for publication October 30 1961; accepted May 31 1962 *This investigation was supported by research gram A-3560 (C1) and by training grants 2A-5025 (C5) and 2A-5155 from the National Institute of Arthritis and Metabolic Diseases U. S. Public Health Service. Submitted in honor of Chester S. Keefer M.D. and the Golden Anniversary of the Evans Memorial Department of Clinical Research Boston Mass. Present address : Dept. of Medicine University of Texas Southwestern Medical School Dallas Tex. SUMMARY A method using constant perfusion of the colon via an orally introduced tube was used to study unidirectional water fluxes as well as absorption of water and electrolytes in the colon of healthy intact men. The perfusion fluid was 0.85 per cent sodium chloride solution containing tritiated water and a nonabsorbable reference substance polyethelene glycol. The test solution was sampled via a rectal tube in all cases and in three cases in the midcolonic area as well. A total of 36 test periods of 20 minutes each was carried out in seven subjects. Under the conditions of our experiments the entire colon absorbed an the average 1.7 ml of water 0.28 mEq of sodium and 0.39 mEq of chloride per minute and at the same time secreted 0.031 mEq of potassium and 0.18 mEq of bicarbonate per minute. The mean water flux out of the lumen was 7.8 ml per minute and flux into the lumen was 6.0 ml per minute. Larger unidirectional water fluxes were observed in the right than in the left colon. ___MH

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WATER AND SALT ABSORPTION IN THE HUMAN COLON * 

WATER AND SALT ABSORPTION IN THE HUMAN COLON *