Mathematical models for the study of the metabolic pattern of sulfate

Journal/Book: Reprinted from THE JOURNAL OF LABORATORY AND CLINICAL MEDICINE St. Louis. Vol. 60 No. 1 Pages 53-63 1962. (Printed in the U. S. A.). 1962;

Abstract: A mathematical model is formulated to describe sulfate metabolism in patients based on measurement of radioactivity in serum and urine following the injection of NaS35O4. Although the major portion of the intravenously administered radioactive sulfate is rapidly excreted in the urine a significant portion of the administered dose is retained. It was found that in order to detect this retention and evaluate its metabolic turnover rate it was necessary to study subjects for at least 72 hours or longer. Some of the apparently metabolized S35O4 rapidly returned to the serum indicating a fast turnover rate in a rapidly exchanging metabolic pool while a fraction remained in a slowly exchanging metabolic pool. Thirty-four studies were performed on 5 normal subjects and 27 patients with various diseases. The metabolic patterns of sulfate as described by our model are not specific for any of the diseases studied. In one Patient with cirrhosis and ascites the metabolic pattern was similar in 2 studies performed 4 months apart. Another study an this subject was performed between these control studies while the patient was on glucocorticoid therapy and a marked impairment of the incorporation of sulfate in the metabolic pool was demonstrated. From the Section of Gastroenterology Department of Medicine Emory University School of Medicine. Grady Memorial Hospital and Statistics Section Epidemiology Branch Communicable Disease Center Public Health Service United States Department of Health Education and Welfare. . . .

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