STUDIES ON SULFATION FACTOR (SF) ACTIVITY OF HUMAN SERUM The effects of oestrogen and X-ray therapy an Serum SF activity in acromegaly.

Journal/Book: ACTA ENDOCRINOLOGICA 37 138-147 1961. 1961;

Abstract: Department of Endocrinology and Metabolism Karolinska sjukhuset Stockholm ABSTRA

Keyword(s): The effect of X-ray therapy and oestrogens on serum SF activity was studied in six acromegalic patients. X-ray therapy produced questionable clinical effects and no change of the serum SF level. In two subjects oestrogen resulted in a normal serum SF level which was paralleled by marked clinical improvement. In the other four cases the serum SF level was not affected although two of these patients showed minor clinical improvement. The measures available for the treatment of acromegaly are radiation to the pituitary gland administration of oestrogens and excision of the tumour. However it has been difficult to assess the clinical results because of the lack of good objective criteria of the activity of acromegaly. The measurement of plasma growth hormone levels would be the ideal method of objectively evaluating the results of therapy. It has been demonstrated that the determination of the sulfation factor (SF) activity of human serum is a measure of growth hormone activity (Daughaday et al. 1959; Almqvist et al. 1961). The aim of the present work was to estimate the effect of oestrogen and X-ray therapy an the clinical activity and serum SF activity in acromegaly. ___MH

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