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July 2021

HOMOIOSTASE DES ARTERIELLEN CO2-DRUCKS UND ANPASSUNG DER LUNGENVENTILATION AN DEN STOFFWECHSEL ALS LEISTUNGEN EINES REGELSYSTEMS

Journal/Book: Sonderdruck aus "Klinische Wochenschrift" 38. Jahrgang 8. Heft 15. April 1960 S. 366-376. 1960;

Abstract: Aus dem Physiologischen Institut der Universität Göttingen Summary. The effect of alveolar ventilation changes upon alveolar CO2 partial pressure is described by the alveolar equation which is the formula of a hyperbolic function. The effect of changes of alveolar CO2 partial pressure upon lung ventilation if inspiratory CO2 is varied is approximated by a linear relationship called the CO2 response curve. The alveolar CO2 partial pressure and the corresponding alveolar ventilation in a given situation are determined as the intercept of both functions and can be found either graphically or by combination of both equations. An assumption an the relationship of total ventilation to alveolar ventilation must be made for this purpose. The derived formulae (4 5 and 6) allow to predict alveolar CO2 partial pressure alveolar ventilation and total ventilation for any given inspired CO2 partial pressure and for any given CO2 output. The formulae describe a regulating system which serves CO2-homeostasis as well as adaptation of ventilation to metabolic needs. The influences of pH and of oxygen partial pressure are considered as modifying the system. The pH influence acts an the intercept of the CO2 response curve with the pCO2 axis and the pO2 influence acts an the slope of this curve. The additional influence of muscular work and of other influences an the drive of ventilation can be considered by their effect an the same parameters of the CO2 response curve. ___MH


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