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Pulmonary resistance and compliance with concurrent radioactive sulfur distribution in dogs breathing S35O21

Journal/Book: Reprinted from JOURNAL OF APPLIED PHYSIOLOGY VOI. 15 NO. 1 January 1960 Printed in U.S.A.. 1960;

Abstract: Department of Medicine Vanderbilt University School of Medicine Nashville Tennessee BALCHUM OSCAR J. JERZY DYBICKI AND GEORGE R. MENEELY. Pulmonary resistance and compliance with concurrent radioactive sulfur distribution in dogs breathing S35O2. J. Appl. Physiol. 15(1) 626. 1960.-Ten dogs breathed S35O2 via a tracheal cannula in concentrations ranging from 1.8 to 148 p p.m. There was a decrease in the compliance of the lungs and thorax after 10-15 minutes of inhalation and an immediate and marked increase in the nonelastic resistance to breathing. S35 was found to be highest in concentration in the trachea lungs and hilar lymph nodes and next highest in the kidneys and esophagus. A relatively uniform and low concentration was noted in other tissues such as the heart muscle liver spleen and striated muscle. S35O2 when inhaled was absorbed quickly distributed widely to many tissues and readily gained access to many tissues including the brain. Received for publication April 28 1959. 1 This work was supported in part by Public Health Service Contract SAph 70219 Air Pollution Medical Program Experimental. Some facilities were made available through grants-in-aid from the National Institute of Arthritis and Metabolic Diseases (2A5129) the Army Medical Research and Development Command (DA-49-007-MD-995) the American College of Chest Physicians and the United States Steel Research Foundation Inc. 2 Present address : Dept. of Medicine University of Southern California School of Medicine Los Angeles Cal. 3 Rockefeller Foundation Research Fellow Gdansk Poland. THE MILIEU EXTÉRIEUR is again becoming the subject of much interest and investigation. The great technological advances of the past several decades and the accompanying industrialization have resulted in a steadily increasing contamination of man's atmosphere by foreign gases and substances to an extent never before realized. Sulfur dioxide is one of these pollutants produced by the combustion of sulfur-containing coal and fuel oil. Its output into our atmosphere is measured in hundreds of tons per day. Aside from its irritative action an the respiratory tract little has been known concerning the details of its physiologic actions until recently. Widdicombe (1 2) has used sulfur dioxide in investigating tracheobronchial reflexes and Amdur and Mead (3) have studied its effect upon pulmonary resistance and compliance. The distribution of S35O2 in rats and mice after inhalation has been studied in a qualitative fashion by Bystrova (4) by the direct counting of tissues slices for beta ray activity. She found sulfur dioxide to be widely distributed and present in many tissues including the trachea lungs liver spleen kidneys and brain. ... ___MH

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