EFFECT OF AIR FLOW RESISTANCE ON VENTILATION AND RESPIRATORY MUSCLE ACTIVITY

Journal/Book: The Journal of The American Medical Association December 27 1958 Vol. 168 pp. 2245-2249. 1958;

Abstract: B. Raymond Fink M.D. Shih-Hsun Ngai M.D. and Duncan A. Holaday M.D. New York From the Department of Anesthesiology Columbia University College of Physicians and Surgeons and the Anesthesiology Service Presbyterian Hospital. Read before the Section on Anesthesiology at the 107th Annual Meeting of the American Medical Association San Francisco June 26 1958. Summary The effect of added airway resistance on ventilation and respiratory muscular activity was studied in decerebrate cats before and during anesthesia. The ventilation was reduced with increased airway resistance in spite of augmented muscular activity. The reduction of ventilation was proportional to the magnitude of the resistance. General anesthesia with pentobarbital nitrous oxide and ether aggravated this ventilatory disturbance; the impairment became progressively greater with deeper anesthesia. This study was supported by a grant from the National Institutes of Health U. S. Public Health Service. ___MH

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