I. FACTORS INFLUENCING ABSORPTION

Journal/Book: IRON ABSORPTION J. Lab. & Clin. Med. Vol. 51 Number 1 Pages 24-36 January 1958. 1957/1958;

Abstract: WITH THE TECHNICAL ASSISTANCE OF B. LODEN AND A. MELLY From the Department of Medicine School of Medicine University of Washington Seattle Wash. *In receipt of Lederle Traveling Fellowship for South Afrlca. Present address: Department of Medicine University of Witwatersrand Medical School Hospital Street Johannesburg South Africa. SUMMARY Iron absorption has been quantitated by a double isotope method by stool recovery and by comparative measurements of iron absorption from two compounds as they appeared within the red cell mass. Employing these isotope measuring techniques the regulation of absorption of small and large doses of iron has been studied. Both the size of iron Stores and the rate of erythropoiesis have been shown to influence the absorption of iron. The larger the iron stores the less iron absorbed whereas the greater the red cell production the greater the amount of iron absorbed. Absorption in normal and phlebotomized subjects and in patients with iron deficiency was measured. The effects on absorption of the amount of iron the form in which it is administered and of supplements were also evaluated. schö

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