THE URINARY EXCRETION OF SODIUM AND POTASSIUM DURING THE PYROGENIC REACTION IN MAN1 2

Journal/Book: Reprinted from THE JOURNAL OF CLINICAL INVESTIGATION Vol. XXXV No. 9 pp. 947-953 September 1956. 1956;

Abstract: From the Veterans Administration Hospital West Haven Connecticut and The Department of Internal Medicine Yale University School of Medicine New Haven Conn. Submitted for publication December 7 1955 ; accepted May 10 1956 1 A preliminary report of this study has appeared in abstract form (1). 2 Supported by grants from The American Heart Association and the Greenwich Health Association and the National Heart Institute National Institutes of Health Public Health Service. 3 Present address : Department of Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania. SUMMARY A study was made of the effect of the pyrogenic reaction as elicited by triple typhoid vaccine an the urinary excretion of sodium and potassium in 16 normal human subjects. No systematic change in the excretion of these ions was observed in febrile or afebrile subjects during either the early transient period of renal vasoconstriction or the late sustained period of renal hyperemia. A reduction in urine volume occurred during the vasoconstrictive phase in association with a decrement in glomerular filtration rate and the urine became more concentrated with respect to sodium and potassium ions. ___MH

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