GASTROINTESTINAL WATER AND ELECTROLYTES. I. THE EQUILIBRATION OF RADIOSODIUM IN GASTROINTESTINAL CONTENTS AND THE PROPORTION OF EXCHANGEABLE SODIUM (Nae) IN THE GASTROINTESTINAL TRACT 1

Journal/Book: Reprinted from THE JOURNAL OF CLINICAL INVESTIGATION VOI. XXXV No.5 pp. 502-511 May 1956 Printed in U. S. A.. 1956;

Abstract: (From the Department of Medicine University of California School of Medicine and the San Francisco Hospital San Francisco Calif.) 1 This work was carried out under grants from the American Heart Association the United States Public Health Service (Grant No. H-1441) the Fleischmann Foundation the San Francisco Heart Association the Paul and Susan Gardiner Fund and the McKee Fund assigned by the Medical Research Committee of the University of California School of Medicine San Francisco. 2 Established Investigator of the American Heart Association. SUMMARY Intraluminal gastrointestinal sodium content was measured in rabbits and in humans studied postmortem. In the former gut sodium was referred to Nae estimated with Na24 while in the latter gut sodium was referred to predicted Nae values. Total exchangeable sodium averaged 46.0 ± 2.0 mEq. per kgm. of body weight in rabbits. Of this 14.2 ± 2.4 per cent was found to be in the gastrointestinal tract with 0.9 ± 0.4 per cent in the stomach 3.2 ± 1.2 per cent in the small intestine and 10.2 ± 2.1 per cent in the proximal half of the large intestine. Radiosodium exchange equilibrium was virtually complete 24 hours after injection at all levels of the gastrointestinal tract. Fasting periods of 8 to 43 hours did not affect the quantity or distribution of gastrointestinal sodium to any appreciable extent. No significant difference in either Nae or the quantity of intraluminal gastrointestinal sodium was found between male and female rabbits. Human subjects at postmortem after a variety of diseases had relatively small amounts of intraluminal gastrointestinal sodium ; the mean values were 1.6 per cent of the predicted Nae in the "total" gastrointestinal tract with 0.45 per cent in the stomach 0.74 per cent in the small bowel and 0.36 per cent in the proximal portion of the large bowel. These data however cannot be taken as a reliable guide to the quantity of intraluminal sodium in living man. The implications of these data are discussed in terms of the dynamics of sodium transport across the intestinal mucosa and the anatomy of body sodium. . . .

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