THE EFFECT OF OBSTRUCTION TO BREATHING ON THE VENTILATORY RESPONSE TO CO21

Journal/Book: Reprinted from THE JOURNAL OF CLINICAL INVESTIGATION VOI. XXXV No. 11 pp. 1286-1290 November 1956. 1956;

Abstract: BY R. M. CHERNIACK2 AND D. P. SNIDAL (From The Department of Physiology and Medical Research the University of Manitoba and the Clinical Investigation Unit Deer Lodge (D.V.A.) Hospital Winnipeg Canada) (Submitted for publication May 7 1956; accepted August 6 1956) 1 This study was supported in part by the Department of Veteran Affairs (Grant No. 17-55) and in part by the National Research Council (Canada) (Grant No. M.P. 548). 2 Markle Scholar in Medical Science. SUMMARY 1. The maximum ventilatory response to CO2 was lower in 20 emphysematous subjects than in six normal subjects while the CO2 response curve was lower in four emphysematous patients than in two normal subjects. 2. In normal subjects artificial obstruction to respiration resulted in a fall in maximum breathing capacity in the ventilatory response to CO2 and in a diminished CO2 response curve. 3. In emphysematous patients alleviation of airway obstruction resulted in an increase in maximum breathing capacity in the ventilatory response to CO2 and in the slope of the CO2 response curve. 4. Little if any difference in the response to inhaled C02 was found between patients with obstructive disease and normal subjects with artificial airway obstruction. schö

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