CORRELATION BETWEEN CAPILLARY RESISTANCE AND CIRCULATING EOSINOPHILS

Journal/Book: Reprinted from THE JOURNAL OF LABORATORY AND CLINICAL MEDICINE. St. Louis. Vol. 43 No. 3 Pages 395-405 March 1954.. 1953/1954;

Abstract: From the Departments of Pediatrics of Physiology and Pharmacology and of Surgery The Creighton University School of Medicine. This work represents part of a project supported by the Cardiovascular Section of the United States Public Health Service and by The Creighton University School of Medicine. Received for publication Aug. 10 1953. SUMMARY The correlation between capillary resistance and circulating eosinophils was studied in seven experimental conditions : following adrenalectomy in the normal rat and dog during administration and withdrawal of cortisone in the adrenalectomized rat during prolonged administration of cortisone in the adrenalectomized rat and dog during prolonged administration of cortisone in the normal dog after cold stress and forced muscular exercise in the normal rat and during prolonged fasting in the normal dog. A good inverse correlation was found in any situation presumably connected with a change in cortisone concentration of the body. (a) If cortisone concentration increases (cortisone administration to adrenalectomized or normal animals first phase of stress response presumably associated with ACTH discharge) the capillary resistance rises and the eosinophils drop. (b) If cortisone level decreases (cortisone withdrawal in adrenalectomized or normal animals adrenalectomy in normal rat second phase of stress response presumably connected with cortical hypofunction) the capillary resistance precipitously drops and eosinophilia occurs. A good inverse correlation (persistent high capillary resistance and persistent low eosinophil level) was found in any situation in which a high cortisone level was maintained during a long period of time by either exogenous (cortisone administration) or endogenous method (protracted stress). No persistent correlation was found in any situation connected with a permanently low cortisone level in the animals. After adrenalectomy or cortisone withdrawal there is at first a seesaw movement : the capillary resistance drops and eosinophilia sets in. This good correlation fades however when the cortisone level remains low in that the high eosinophil count returns to normal average levels whereas the capillary resistance remains permanently low. In these conditions the eosinophils cease to reflect the cortisone level and only the capillary resistance remains to be a reliable indicator. schö

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