BRONCHOSPIROMETRY II. Experimental Observations and Theoretical Considerations of Resistance Breathing

Journal/Book: Reprinted from The JOURNAL OF LABORATORY and CLINICAL MEDICINE St. Louis Vol. 39 No.6 Pages 935-953 June 1952. 1952;

Abstract: From the Thorndike Memorial Laboratory Second and Fourth Medical Services (Harvard). Boston City Hospital and the Department of Medicine. Harvard Medical School. Boston; the Physiology Laboratory Surgical Service Sanatorium Division of the Boston City Hospital. Mattapan and the Department of Surgery Boston University School of Medicine; the Department of Physiology Harvard School of Public Health. Boston; and the Surgical Clinic. Sabbatsberg Hospital Stockholm Sweden SUMMARY The resistances to air flow at volumetric flow rates from 5 to 40 liters per minute were measured for both lumina of the catheters by Gebauer Zavod Norris and Carlens. They were four to eighteen times greater than the resistances encountered in the normal human respiratory passage and they were at least equal to and at worst four times greater than pressure gradients encountered in airways of patients with severe bronchial asthma or pulmonary emphysema. Unequal resistance of the two sides was shown to favor the right hing with the two lumen catheters and the left with the one-lumen tube. The shape of the pressure-flow curves showed a logarithmic relationship between rate of flow and resistance. It was shown that this favors the lung with impaired ventilation during bronchospirometry. . . .

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