Aluminium release from phosphate binders - an in vitro study with special regard to the digestion process and food and drug composition

Author(s): Kluthe, R.

Journal/Book: Trace Elements in Medicine. 1989; 6: 134-138.

Abstract: Aluminum (Al) containing phosphate (P) binders have been widely used as a therapeutic measure for the prevention and the treatment of P retention. Especially in patients with renal insufficiency A1 accumulation may occur and cause encephalopathy and osteomalacia. The aim of our study was to examine different phosphate binding agents for their A1 release in the digestive process and their contribution to Al adsorption and accumulation. We used an in vitro digestion model which simulated the digestion process in stomach and gut, producing close to physiological conditions (enzymes, bile, pH, foodstuff). Aluminum release from different Al containing drugs varied significantly depending an the type of drug and the stomach and gut conditions as well as foodstuff matrix. The results suggest that the type of A1 containing drug as well as the type of food ingested have to be taken into consideration when estimating the efficacy and the therapeutic risk of different phosphate binders.

Keyword(s): aluminum release

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