Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003 Jun; 23(6): 445-6, 454.

[Effect of xinmaitong on wild-type p53 gene expression in rabbits with carotid endothelial injury]

Guan CY, Zhang WG, Zhou SN.

Xiamen Hospital of TCM, Fujian 361000.

OBJECTIVE: To explore the mechanism of prevention and treatment of post-PTCA restenosis with Xinmaitong (XMT). METHODS: Rabbit carotid endothelial injury model was established using Fishman air drying method. Effect of XMT on model rabbits wild-type p53 gene expression was observed by tissue in situ hybridization. RESULTS: p53 gene expression appeared on the 3 days after operation, enhanced on the 7 days, reached the peak on the 14th day, weakened on the 21th, and still showed on the 28th day. The strongest expression was shown in rabbits treated by XMT, second in those treated by Warfarin, and the weakest in the operated control group. CONCLUSION: XMT could promote the high expression of wild-type p53 gene expression in rabbit with carotid endothelial injury, which is possibly one of the important mechanism of XMT in preventing and treating arterial restenosis.