Fitoterapia. 2003 Jul; 74(5): 493-6.

Antifungal activity of the methanolic extract and alkaloids of Glaucium oxylobum.

Morteza-Semnani K, Amin G, Shidfar MR, Hadizadeh H, Shafiee A.

Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. [email protected]

The methanolic extract and total alkaloids of the aerial parts of Glaucium oxylobum exhibited good activity against Microsporum gypseum, Microsporum canis, Trichophyton mentagrophytes and Epidermophyton floccosum. Four alkaloids, dicentrine, glaucine, protopine, and alpha-allocryptopine, were identified as the compounds responsible for the antifungal activity of this plant.