Fitoterapia. 2003 Jul; 74(5): 439-44.

Further degradation product of hyperforin from Hypericum perforatum (St John's Wort).

Vajs V, Vugdelija S, TrifunoviÄ S, KaradziÄ I, JuraniÄ N, Macura S, MilosavljeviÄ S.

Institute of Chemistry, Technology and Metallurgy, Njegoseva 12, Serbia and Montenegro, Belgrade 11000, Yugoslavia.

Repeated examination of the aerial parts of Hypericum perforatum yielded a new degradation product of hyperforin (1) namely deoxyfurohyperforin A (2), together with the previously identified furohyperforin (3), furoadhyperforin (4), furohyperforin A (5a and 5b), pyrano[7,28-b]hyperforin (6) and 3-methyl-4,6-di(3-methyl-2-butenyl)-2-(2-methyl-1-oxopropyl)-3-(4-methyl-3-pentenyl)-cyclohexanone (7). The antimicrobial activity of the compounds 3, 5a and 5b, 6 and 7 was tested against Staphylococcus aureus, Candida albicans, Bacillus subtilis and Escherichia coli.