Fitoterapia. 2003 Jun; 74(4): 375-7.

Antifungal activity of sterols and triterpenes isolated from Ganoderma annulare.

Smania EF, Delle Monache F, Smania A, Yunes RA, Cuneo RS.

Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Catarina, Florianopolis, SC 88040-900, Brazil.

Three sterols, 5alpha-ergost-7-en-3beta-ol, 5alpha-ergosta-7,22-dien-3beta-ol and 5,8-epidioxy-5alpha,8alpha-ergosta-6,22-dien-3beta-ol and five triterpenes, applanoxidic acids A, C, F, G and H, have been isolated from Ganoderma annulare. The applanoxidic acids A, C and F were found to inhibit the growth of the fungi Microsporum cannis and Trichophyton mentagrophytes at concentrations of 500 to 1000 microg/ml.