Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003 Apr; 23(4): 272-4.

[Regulatory effect of yishou tiaozhi tablet on lipids in patients with primary hyperlipidemia]

Sun L, Jiang J, Chen XY.

Faculty of TCM, Medical College, Jinan University, Guangzhou 510632.

OBJECTIVE: To study the regulatory effect of Yishou Tiaozhi Tablet (YSTZT) on blood lipids in patients with primary hyperlipidemia. METHODS: One hundred and sixty-eight patients with primary hyperlipidemia were randomly divided into two groups. The treated group was treated with YSTZT 4 tablets 3 times a day, and the control group was treated with Zocor by oral taking 1 tablet before sleep every evening. The therapeutic course for both groups was 60 days. The effect in regulating blood lipids in patients was observed. RESULTS: The levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), arteriosclerosis index (AI), apo-lipoprotein B (apoB), TC/HDL-C lowered and apoA/apoB ratio increased obviously in the treated group. As compared the effects between the two groups, the lowering of TC, AI and apoB in the two groups were similar (P > 0.05), effect of YSTZT in lowering TG was superior but in lowering of LDL-C was inferior to those of Zocor respectively (all P < 0.01). The effect of both remedies in elevating HDL-C was not satisfactory. The total effective rate of YSTZT was 91.9%, its individual effects were similar to those of SJZ respectively except in lowering TG and raising HDL-C. The adverse reaction occurred in YSTZT treatment course was mild without any influence on the medication. CONCLUSION: YSTZT had definite regulatory effect on the blood lipids and lipoproteins in patients with hyperlipidemia.